| Title | [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats] | | Author(s) | Han J, Wan H, Ge L, Zhu Z, Guo Y, Zhang Y, Li J | | Institution | Traditional Chinese Medicine University of Zhejiang, Institute of Cardio-Cerebrovascular Diseases, Hangzhou 310053, China. | | Source | Zhongguo Zhong Yao Za Zhi 2009 Jun; 34(11):1422-5. | | Abstract | OBJECTIVE: To observe the effect of 3'-methoxy puerarin on cerebral infarction volume and free radical change of focal cerebral ischemia-reperfusion injury in rats and discuss the protective effect of 3'-methoxy puerarin on the cerebral ischemic/ reperfusion injury.
METHOD: The thread method was used to induce middle cerebral artery embolization, to establish the focal cerebral ischemia-reperfusion model. Rats were divided into five groups: the sham and model group, the two-dose group (5, 10 mg x kg(-1) x d(-1)) of 3'-methoxy puerarin and nimodipine group (5 mg x kg(-1) x d(-1)). The behavior changes and volume of cerebral infarction were observed, and the leves of SOD and the content of MDA were measured.
RESULT: 3'-methoxy puerarin could significantly improve the symptoms of neurological deficit and reduce the infarct volume, and increased SOD activity and reduced the content of MDA of cortex in cerebral ischemia-reperfusion injury rat, the action of 10 mg x kg(-1) of 3'-methoxy puerarin is more remarkable.
CONCLUSION: 3'-methoxy puerarin has protective effect on focal cerebral ischemia-reperfusion injury in rat. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19771877 |
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